Bleocin-S Bleomycin 15 mg (15,000 IU of bleomycin) 1 vial
Bleomycin is a treatment for a number of types of cancer. You might have it as part of a clinical trial for some types of cancer.
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Buy online Bleocin-S (Bleomycin) 15 mg. 1 vial contains bleomycin sulfate in an amount equivalent to 15,000 IU of bleomycin.
Bleocin-S aka Bleomycin is a treatment for a number of types of cancer. You might have it as part of a clinical trial for some types of cancer.
Bleocin-S aka Bleomycin is a type of antibiotic that is poisonous to cells. It binds to the cancer cells’ DNA so that the cells can’t divide or grow. It also causes free radicals to be made inside the body. Free radicals are overactive oxygen atoms that damage DNA.
Active ingredient: bleomycin sulfate;
1 vial contains bleomycin sulfate in an amount equivalent to 15,000 IU of bleomycin.
Lyophilisate for solution for injection.
Antineoplastic agents. Cytotoxic antibiotics and related preparations. Other cytotoxic antibiotics.
- lung cancer (especially primary or metastatic squamous cancer);
- skin cancer;
- cervical cancer;
- malignant tumors of the head and neck;
- esophageal carcinoma;
- thyroid cancer;
- Hodgkin’s disease (lymphogranulomatosis);
- kidney cancer;
- penile cancer;
- malignant testicular tumors;
- non-Hodgkin’s lymphoma;
- malignant pleurisy (as a sclerosing agent).
Bleocin-S aka Bleomycin is contraindicated if the patient has: intolerance to the components that make up the drug, acute pulmonary infections, impaired lung function, acute renal failure, ataxia-telangiectasia and heart failure. Children under the age of 18 are also a contraindication to the use of the drug. In case of previous or concomitant radiation therapy, impaired renal function, acute viral or infectious diseases, as well as persons whose age is older than 70 years, Bleocin-S should be used with extreme caution.
In the case of an overdose of the drug Bleocin-S aka Bleomycin in a patient, manifestations of tachycardia, fever, arterial hypotension and general signs of shock are possible. Symptomatic treatment is applied, and in case of complications of the respiratory system, it is recommended to use broad-spectrum antibiotics and corticosteroids.
The use of the drug Bleocin-S raises the risk of various negative reactions, such as: dyskeratosis, hypertrophic skin changes, skin tightening, vulvitis redness, scleroderma, hyperkeratosis, skin hyperpigmentation, alopecia, deformity and fragility of the nails, conjunctivitis, pruritus, striae, hyperesthesia and swelling of the distal (nail) phalanges of the fingers, changing the color of the nails. Bleocin-C very often causes skin disorders, but in most cases, after the end of the course of treatment, they disappear.
Allergic reactions, urticaria, anaphylactic reactions, rashes, blistering of the skin are possible. After application of the first or second dose, usually several hours after the administration of the drug, there may be: fever, confusion, lowering blood pressure, chills, fever, wheezing.
Also, the use of the drug can lead to the development of interstitial pneumonia, anorexia, pulmonary fibrosis, nausea, stomatitis, vomiting, weight loss and diarrhea.
Other side effects that Bleocin-S can cause: cerebral arteritis, myocardial infarction, thrombotic microangiopathy, Raynaud’s syndrome, fatigue, pleuropericarditis, pain in the tumor areas or at the injection site, slight bone marrow suppression, changes in liver function tests and kidney.
Storage conditions of the drug Bleocin-S: inaccessibility to children, room temperature not higher than + 25 ° C, the original packaging, the storage location should be protected from moisture and direct sunlight.
Shelf life of the drug is 36 months.
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Lyophilisate for solution for injection
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Lumière Pharma, Ltd.
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The preparation Bleocin-S is used for intravenous, intramuscular, subcutaneous or intrapleural administration, the choice of dose and mode of administration is selected for each case individually. Immediately before use, the drug is diluted in sodium chloride solution, for intravenous administration one vial of the drug is 15 mg diluted in a volume of 5 to 20 ml, for intramuscular or subcutaneous in a volume of 5 ml, for intraarterial administration the drug is diluted in 200 to 1000 ml. The introduction of Bleocin-S is quite a painful procedure, so the drug can be mixed with 1.5 – 2 ml of a 1% solution of trimecaine.
The recommended dose for intramuscular, intravenous or subcutaneous administration is 15-20 mg (10 mg / m 2), which is divided into two separate doses. For subcutaneous administration, the daily dose is used as a continuous infusion.
For head and neck tumors, intra-arterial administration is used at a dosage of 5-15 mg.
Intrapleural administration is applied once or twice a week once, in 50-100 ml of the solution 60 mg of the drug is diluted.
The initial dose of the drug can be reduced, since there is a greater likelihood of an anaphylactic reaction, if there is no acute reaction, then further treatment is continued at the usual dose. Also reduce the dose during radiotherapy. In renal insufficiency, the dose is adjusted depending on the serum creatinine concentration.
The total cumulative dose of Bleocin-S should not exceed 400 mg, and for further continuation of therapy, lung function should be evaluated.
For elderly patients, the dose of the drug is determined according to age:
Patients aged 80 years and older, the total dose is 100 mg;
Patients aged 70 to 80 years, the total dose is 150-200 mg;
Patients aged 60 to 70 years, the total dose is 200-300 mg;
For patients under the age of 60, the total dose is 100 mg.
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