Buserelin / Receptol / Veterelin 0.004 mg/ml, 10 ml

Buserelin / Receptol / Veterelin 0.004 mg/ml, 10 ml

$20.00

Veterelin / Buserelin treatment of anovulatory anoestrus, delayed ovulation, cystic ovaries, for the improvement of pregnancy rate, to induce ovulation in cows, mares.
Active substance: Buserelin 0.004 mg (equivalent to 0.0042 mg Buserelin acetate).

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Description

Buy online VETERELIN / Buserelin 0.004 mg/ml, solution for injection for cattle, horses, pigs, and rabbits.
INGREDIENTS:
Active substance: Buserelin 0.004 mg (equivalent to 0.0042 mg Buserelin acetate);
Excipient: Benzyl alcohol 10 mg.

A ready-to-use colourless, aqueous injection solution for parenteral administration. Each ml contains 4 μg Buserelin and 10 mg benzyl alcohol, Ph.Eur., as antimicrobial preservative. Buserelin is equivalent to the natural LH/FSH releasing hormone produced in the hypothalamus. It causes simultaneous release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the anterior pituitary.
PHARMACOLOGICAL PROPERTIES:
ATCVet Code: QH01CA90
Pharmacotherapeutic group: Gonadotropin-releasing hormones.

PHARMACODYNAMIC PROPERTIES:
Buserelin is a peptide hormone which is chemically analogous to the releasing hormone (RH) of the luteinising hormone (LH) and follicle stimulating hormone (FSH) thus a gonadotrophin releasing hormone (GnRH) analogue.
The mode of action of the veterinary medicinal product corresponds to the physiologic-endocrinological action of the naturally occurring gonadotrophin releasing hormone.
GnRH leaves the hypothalamus via the hypophyseal portal vessels and enters the anterior lobe
of the hypophysis. Here it induces the secretion of the two gonadotrophins FSH and LH into the peripheral blood stream. These can act physiologically to cause maturation of ovarian follicles, ovulation and lutenization in the ovary.

PHARMACOKINETIC PROPERTIES:
After intravenous administration, Buserelin is degraded rapidly: its half-life is 3 to 4.5 minutes in rat and 12 minutes in guinea pigs. Buserelin is accumulated in the
pituitary gland, liver and kidneys where the substance is degraded by enzymes into small peptides fragments with negligible biologic activity. The main excretion route is in
the urine.

INDICATIONS::
FOR COWS (CATTLE)

  • Ovulation induction or delayed ovulation;
  • Treatment of anoestrus;
  • Treatment of follicular cysts with or without symptoms of nymphomania;
  • Improvement of conception rate in artificial insemination procedures, also after synchronisation of oestrus with a PGF2α analogue. Results may however vary depending on breeding conditions;

FOR MARES (HORSES)

  • Ovulation induction and thereby to synchronise ovulation more closely with mating in mares;
  • Treatment of follicular cysts – with or without symptoms of nymphomania;

FOR RABBITS (DOES)
Improvement of conception rate and ovulation induction at post partum insemination.
FOR PIGS (Nulliparous cycling gilts )
Ovulation induction after oestrus synchronization with an analogue of progestagen (altrenogest) in order to perform a single artificial insemination.

CONTRAINDICATIONS:
Do not use in animals with known hypersensitivity to the active ingredient or to the excipients.

PRECAUTIONS:
Following withdrawal of the first dose, use the product within 24 hours. Discard unused material. Observe aseptic precautions.
Use of the product contrary to the recommended protocols may result in the formation of follicular cysts which may detrimentally affect fertility and prolificacy.
Avoid eye and skin contact with the solution for injection. In case of accidental contact, rinse thoroughly with water. Should skin contact with the product occur, wash the exposed area immediately with soap and water, as GnRH analogues may be absorbed through the skin.
Pregnant women should not administer the product, as buserelin has been shown to be foetotoxic in laboratory animals.
Women of child-bearing age should administer the product with caution.
When administering the product, care should be taken to avoid accidental self-injection by ensuring that animals are suitably restrained and the application needle is shielded until the moment of injection.
In case of accidental self-injection, seek medical advice immediately and show the package leaflet or the label to the physician. Wash hands after use.

ADVERS REACTIONS:
None.

INTERACTION WITH OTHER MEDICAMENTS:
None known.

OVERDOSE:
In the case of repeated administrations of a dose corresponding to 3.5 ml of product, reduced food consumption may be observed in gilts after the 2-nd injection. This effect is transient and no specific treatment is required.

WITHDRAWAL PERIOD:
Meat and offal: zero days;
Milk: zero hours.

SHELF LIFE:
Shelf life of the veterinary medicinal product as packaged for sale: 24 months;
Shelf life after first opening the immediate packaging: 8 hours.

STORAGE:
Store below 25°C. Protect from light.

PACKAGING:
Colourless glass vials of 10 (or 20) ml, with bromobutyl rubber closure and aluminium capsules with Flip-off opening ring in PP of blue colour.

Additional information

Weight 120 g
Forms of release

Solutions for injections

Volume / Weight

10 ml

Packing

Glass bottle

Manufacturer

Laboratorios Calier SA

Country/Region of Manufacture

Spain

DOSAGE AND ADMINISTRATION:
Veterelin is preferably given by intramuscular injection. However, the intravenous or subcutaneous routes may also be used if desired. Syringes and needles should be from gamma irradiated packs or freshly sterilised by boiling for 20 minutes, but no alcohol or disinfectant should be used for this procedure.
In cattle, horses and rabbits, the preferred route of administration is intramuscular injection (i.m.), but it may also be injected intravenously (i.v.) or subcutaneously (s.c.).
In pigs, the preferred route of administration is intramuscularly (i.m.), but it may also be injected intravenously (i.v.).

COWS
– Anovulatory anoestrus – 2 mL;
– Synchronisation of oestrus – 2 mL;
– Follicular and Luteal cysts with or without prolonged signs of nymphomania – 5 mL;
– Delayed ovulation – 2.5 mL;
– Improvement in pregnancy rate of cows – 2.5 mL;

MARES:
– Cystic changes of the ovaries with or without prolonged or permanent oestrus – 10 mL;
– To induce ovulation of a mature follicle and thereby to synchronise ovulation more closely with mating in mares – 10mL;
– Anoestrus – 5 mL twice, with an interval of 24 hours.

Special Notes:
Cattle:
For the treatment of anovulatory anoestrus in dairy cows Veterelin, used in conjunction with a progesterone device and a PGF 2α analogue with luteolytic activity
Day 0 2.0mL Veterelin
Insert progesterone device;
Day 7 PGF 2α analogue at recommended luteolytic dose
Remove progesterone device;
Day 8, 9 Inseminate on detection of oestrus;
Day 10 2.0mL Veterelin to non-detected cows and fixed time Artificial insemination immediately or within 24hrs.
OR
Day 0 2.0mL Veterelin
Insert progesterone device;
Day 7 PGF 2α analogue at recommended luteolytic dose
Remove progesterone device;
Day 9 2.0mL Veterelin
Day 10 Fixed time Artificial Insemination 16-20 hours after final Receptal injection.

For the synchronisation of oestrus cows and heifers
Veterelin, when used as part of a 10 day fixed time oestrus synchronisation and insemination regime will increase submission rates and significantly reduce the calving to conception interval. The method comprises Receptal used in conjunction with a PGF 2α analogue with luteolytic activity with or without a progesterone implant device;
Day 0 2.0mL Veterelin;
Day 7 PGF 2α analogue at recommended luteolytic dose;
Day 9 2.0mL Veterelin;
Day 10 Fixed time Artificial Insemination 16-20 hours after final Veterelin injection;
OR
Day 0 2.0mL Veterelin
Insert progesterone device;
Day 7 PGF 2α analogue at recommended luteolytic dose
Remove progesterone device;
Day 9 2.0mL Veterelin;
Day 10 Fixed time Artificial Insemination 16-20 hours after final Receptal injection.

When using fixed time insemination regimes, it is recommended that cows showing signs of oestrus after prostaglandin treatment should be inseminated when observed in oestrus rather than completing the synchronisation programme.

Follicular cysts
In the treatment of follicular cysts in cattle, it is unnecessary and contraindicated to manually express the cysts. A corpus luteum will usually be clearly detectable on either the affected or the normal ovary within about 8 days after administration of Veterelin. The ‘healthy corpus luteum’ can be left to spontaneously
resolve or the time to the next oestrus can be shortened by giving a PGF 2α analogue with luteolytic activity 7-9 days after the Receptal injection. Artificial insemination or service should take place during the first oestrus after treatment. Oestrus should occur within 21 days of Veterelin injection, if not re-examine and retreat if a further cyst has developed.

Delayed ovulation
May be treated at the time of artificial insemination or service, or up to 6-8 hours before. Ovulation is usually induced within 24 hours of treatment.

Improvement in pregnancy rate of cows
Veterelin should be injected at the time of insemination or up to 8 hours before hand. This helps to ensure that ovulation occurs at the correct time after insemination. Improvement of pregnancy rate may also be achieved by a single injection on day 11 or 12 after insemination by helping to prevent luteolysis
and consequent embryo mortality.

Note
The induction of ovulation is not possible in the presence of a functional corpus luteum.

MARES:
In cystic changes of the ovaries, a single treatment is usually sufficient. If 10-14 days after treatment no response (i.e. regression of the cysts or remission of the prolonged or permanent oestrus) is seen, the treatment should be repeated.
In anoestrus mares if no oestrus occurs within 10 days, Receptal should be administered again on the 11th and 12th day after the first treatment.
To induce ovulation of a mature follicle and thereby to synchronise ovulation more closely with mating.
Veterelin should be administered on the first day on which the follicle has reached its maximum size, this being determined by previous clinical history and rectal examinations.
Veterelin is best given approximately 6 hours prior to service. This may be achieved by administering Veterelin in the morning with service in the afternoon of the same day, or alternatively with the injection given in the early afternoon and service in the evening.
The mare should be served again the next morning if she is still in oestrus. If ovulation has not occurred within 24 hours after treatment, then the injection should be repeated.

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