Tazpen Piperacillin Tazobactam 4g/0,5g 1vial
Tazpen aka Piperacillin and Tazobactam injection is used to treat bacterial infections in many different parts of the body. This combination is an antibiotic that belongs to the group of medicines known as penicillins and beta-lactamase inhibitors. It works by killing the bacteria and preventing their growth.
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Buy online Tazpen aka Piperacillin and Tazobactam 4g/0.5g 1 vial
Tazpen aka Piperacillin and Tazobactam injection is used to treat bacterial infections in many different parts of the body.
Tazpen aka Piperacillin and Tazobactam combination is an antibiotic that belongs to the group of medicines known as penicillins and beta-lactamase inhibitors. It works by killing the bacteria and preventing their growth. However, Tazpen aka Piperacillin and Tazobactam will not work for colds, flu, or other virus infections.
Each 4.5 g single-dose vial contains Tazpen sodium equivalent to Piperacillin 4 g and equivalent to Tazobactam (Tazpen) 0.5 g and edetate disodium (dihydrate) (EDTA) 1 mg.
Tazpen is an injectable antibacterial combination consisting of the semisynthetic antibiotic Piperacillin sodium and the beta-lactamase inhibitor Tazobactam sodium for intravenous administration. Piperacillin sodium is derived from D(-)-a-aminobenzylpenicillin. The chemical name of Piperacillin sodium is sodium (2S, 5R, 6R)-6-[(R)-2-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-2-phenylacetamido] – 3,3 –dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane – 2 – carboxylate. Piperacillin sodium is a white, crystalline powder. Piperacillin sodium is freely soluble in water, in alcohol, and in methyl alcohol; practically insoluble in ethyl acetate. Tazobactam sodium is a derivative of the penicillin nucleus. Chemically, Tazobactam is a penicillanic acid sulfone. Its chemical name is sodium (2S-,3S-,5R) – 3 – methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate,4,4-dioxide. Tazobactam sodium is a white to pale yellow non-hydroscopic crystalline powder.
Tazpen also contains the following excipients: sodium hydrogen carbonate, citric acid (monohydrate), EDTA, water for injections and nitrogen.
Tazpen is indicated for the treatment of the following systemic and/or local bacterial infections in which susceptible organisms have been detected or are suspected:
Tazpen, in combination with an aminoglycoside, is indicated for bacterial infections in neutropenic adults or children.
Children Under the Age of 12 Years: In hospitalized children aged 2 to 12 years, drug is indicated for the treatment of intra-abdominal infections including appendicitis complicated by rupture or abscess, peritonitis, and biliary infections. It has not been evaluated in this indication for pediatric patients below the age of 2 years.
Whilst Tazpen is indicated only for the conditions listed above, infections caused by Piperacillin susceptible organisms are also amendable this drug treatment due to its Piperacillin content. Therefore, the treatment of mixed infections caused by this drug susceptible organisms and β-beta lactamase producing organisms susceptible to Tazpen should not require the addition of another antibiotic.
Tazpen is particularly useful in the treatment of mixed infections and in presumptive therapy prior to the availability of the results of sensitivity tests because of its broad spectrum of activity.
Tazpen acts synergistically with aminoglycosides against certain strains of Pseudomonas aeruginosa. Combined therapy has been successful, especially in patients with impaired host defences. Both drugs should be used in full therapeutic doses. As soon as results of culture and susceptibility tests become available, antimicrobial therapy should be adjusted if necessary.
Before you use, tell your doctor of your medical and health history including the following:
— a genetic disorder affecting lungs and kidneys (cystic fibrosis);
— kidney disease;
— liver disease;
— patients are on a low salt diet;
— sensitivity to multiple allergens;
— sexually transmitted infection (gonorrhea);
If you are on gonorrhea therapy, you should be tested for syphilis as well. There is an increased risk of rash or fever in patients with cystic fibrosis.
Before you use Tazpen, tell your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Discuss with your doctor if you are allergic to penicillins, cephalosporins, or beta-lactamase inhibitors.
The use of Tazpen Injection may change aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Elevation in the levels of AST and ALT is seen.
The use of this medicine may change alkaline phosphatase. The levels of alkaline phosphatase get increased.
The use of Tazpen Injection may change the bilirubin level. There is an elevation in bilirubin levels.
The use of this medicine may change partial thromboplastin time. There is prolongation in the partial thromboplastin time.
The use of this medicine may change the blood creatinine level. There is an increase in blood creatinine level.
Get emergency medical help if you have signs of an allergic reaction to Tazpen: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
Common Tazpen side effects may include:
Powdwer for solution, strenght 500 mg.
Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.
Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Tazpen Injection.
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HOW TO USE
Follow directions on the product label, information guide, and provided by your doctor before using Tazpen. Inject this medicine as per your doctor’s instructions.
The typical adult dose of Tazpen is 3375 mg after every six hours totaled 13500 mg (12000 mg piperacillin/1500 mg tazobactam). The typical dose for children is 100 mg/12.5 mg/kg (45.4/5.69 mg/lb) given after every 8 hours. This medicine is commonly used for a period of 7-14 days for a hospital-acquired lung infection, 5-14 days for a stomach infection, and 5-14 days for urinary tract infection. There are no known habit-forming tendencies with this medicine.
You should continue to use this medicine as directed by the doctor even if you feel well.
The injection form of the medicine may be used on the vein. Inject slowly, into the vein over 20-30 minutes. Each vial of Tazpen reconstituted by adding 50 ml of sterile water or 0.9% sodium chloride solution or 5% glucose for injection under aseptic conditions. Shake vigorously for 1-2 minutes. This solution may be further diluted to the desired volume. Shake well again till it is completely dissolved. Syringes are used for the withdrawn of this solution from the vial. The product should be visually examined for particulate matter, damage to the container or discoloration before use.
USE in CHILDREN
If you are giving Tazpen Injection to a child, be sure to use a product that is meant for use in children. Before giving this medicine, use the child’s weight or age to find the right dose from the leaflet or product package. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.
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